Do Tuscan people adhere to meningococcal C vaccination during an emergency campaign?
PDF

Keywords

Meningococcal C invasive disease
Vaccination coverage
Emergency immunization campaign
Population adherence
Tuscany (Italy)

Abstract

Introduction: Tuscany region (Italy) recorded a rise in the number of meningococcal disease cases between January 2015 and February 2016,(52 cases) compared to 2014(16 cases). The aim of this study was to describe the emergency meningococcal C (MenC) vaccination programme in Tuscany and the population’s adherence to the activities performed in the Local Health Unit (LHU) of Florence.

Methods:The MenC vaccination programme and the planning of the prevention and communication activities were analysed in the LHU of Florence. As an indicator of population’s adherence, the vaccination coverage (VC)during the emergency campaignwas investigated and adverse drug reactions (ADR) surveillance was reported.

Results:The communication campaign included a dedicated toll-free telephone number, press releases (newspapers, radio, television, websites), and informative letters addressed to mayors, secondary schools, and sports associations. Citizens aged 11–20 years were the primary target of the campaign. Due to the high incidence of cases among older people, the vaccination was extended to subjectsover 45 years. The population’s adherence to the vaccination campaignwas satisfactory: VC reached 47.1%for the primary target. The ADR reporting rate (3.1/10,000) on meningococcal disease in our study confirmed the safety of the vaccination.

Conclusions:In 2017, only 10 IMD cases were reported, suggesting the effectiveness of the immunization campaign. Similar VC during emergency MenC vaccination programmes have been reached in other Italian regions and other EU countries, too.The achievement of greater vaccination coverage is restricted by a sentiment of hesitancy towards vaccines among the general population.
https://doi.org/10.15167/2421-4248/jpmh2018.59.3.952
PDF

References

European Centre for Disease Prevention and Control. Public health management of sporadic

cases of invasive meningococcal disease and their contacts. Stockholm: ECDC; 2010 Available at: http://ecdc.europa.eu/en/press/news/_layouts/forms/News_DispForm.aspx?List=8db7286c-fe2d-476c-9133-18ff4cb1b568&ID=188 [Last accessed 6 February 2018]

Dickinson FO, Pérez AE, Cuevas IE. Meningococcal disease serogroup C. Risk Manag Health Policy 2012;5:1-15

Stephens DS, Greenwood B, Brandtzaeg P. Epidemic meningitis, meningococcaemia, and Neisseria meningitidis. Lancet 2007;369(9580):2196-210.

Pascucci MG, Di Gregori V, Frasca G, Rucci P, Finarelli AC, Moschella L, et al. Impact of meningococcal C conjugate vaccination campaign in Emilia-Romagna, Italy. Hum VaccinImmunother 2014;10(3):671-6.

Malattie batteriche invasive (sepsi e meningiti). Aspettiepidemiologici. Available at: http://www.epicentro.iss.it/problemi/meningiti/EpidItalia.asp [Last accessed 6 February 2018]

Alfonsi V, D'Ancona F, Giambi C, Nacca G, Rota MC; Regional Coordinators for Infectious Diseases and Vaccinations. Current immunization policies for pneumococcal, meningococcal C, varicella and rotavirus vaccinations in Italy. Health Policy. 2011 Dec;103(2-3):176-83

Bechini A, Levi M, Boccalini S, Tiscione E, Balocchini E, Canessa, et al. Impact on disease incidence of a routine universal and catch-up vaccination strategy against Neisseria meningitidis C in Tuscany, Italy. Vaccine. 2012;30(45):6396-401. doi: 10.1016/j.vaccine.2012.08.019

Tuscan regional government deliberation n° 823 (6 October 2014). Calendario vaccinale della Regione Toscana e direttive in materia di vaccinazioni. Aggiornamento al 2014

Istituto Superiore di Sanità. Dati di sorveglianza delle malattie batteriche invasive aggiornati al 3 aprile 2017. [Italian] Available at: http://www.iss.it/binary/mabi/cont/Report_MBI_20170403_finale.pdf [Last accessed 6 February 2018]

Stefanelli P, Miglietta A, Pezzotti P, Fazio C, Neri A, Vacca P, Voller F, D’Ancona FP, Guerra R, Iannazzo S, Pompa MG, Rezza G. Increased incidence of invasive meningococcal disease of serogroup C / clonal complex 11, Tuscany, Italy, 2015 to 2016. Euro Surveill. 2016;21(12):pii=30176.

Tuscanregionalgovernmentdeliberation n° 367 (30 March 2015). Calendario vaccinale della Regione Toscana e direttive in materia di vaccinazioni

Tuscan regional government deliberation n° 571 (27 April 2015). Prevenzione della diffusione del meningococco C in Toscana. Aggiornamento calendario e direttive aprile 2015

Tuscan regional government deliberation n° 85 (16 February 2016). Prevenzione della diffusione del meningococco C in Toscana. Ulteriori interventi per la promozione della vaccinazione e per lo studio e l’analisi delle possibili cause.

http://www.regione.toscana.it/-/campagna-contro-il-meningococco-c[Last accessed 6 February 2018]

http://www.asf.toscana.it/index.php?option=com_content&view=article&id=2980:vaccinazione-antimeningococco-c&catid=162:informasf-newsinformasf-servizi[Last accessed 6 February 2018]

Istituto Superiore di Sanità. Dati di sorveglianza delle malattie batteriche invasive aggiornati al 23 dicembre 2015. Available at: http://www.iss.it/binary/mabi/cont/Report_MBI_20151223_v4.pdf [Last accessed 6 February 2018]

Gabutti G, Stefanati A, Kuhdari P. Epidemiology of Neisseria meningitidis infections: case distribution by age and relevance of carriage. Journal of Preventive Medicine and Hygiene. 2015;56(3):E116-E120

Azzari C, Nieddu F, Moriondo M, et al. Underestimation of Invasive meningococcal disease in Italy. Emerg Infect Dis 2016 Mar; 22(3)

Kremastinou J, Tzanakaki G, Kansouzidou A, Pagalis A, Danielides V, Kouppari G, et al. Recent emergence of serogroup C disease in Greece. FEMS Immunol Med Microbiol 1999;23(1):49–55

http://www.epicentro.iss.it/problemi/meningiti/report_mening_veneto.asp[Last accessed 6 February 2018]

https://salute.regione.veneto.it/c/document_library/get_file?uuid=b4861725-d3be-4c48-be8f-7333baf21223&groupId=73838[Last accessed 6 February 2018]

Trotter CL, Ramsay ME, Kaczmarski EB. Meningococcal serogroup C conjugate vaccination in England andWales: coverage and initial impact of the campaign. Commun Dis Public Health 2002;5(3):220–5

Campbell H, Borrow R, Salisbury D, Miller E. Meningococcal C conjugate vaccine: the experience in England and Wales. Vaccine 2009;27Suppl 2:B20-9. doi: 10.1016/j.vaccine.2009.04.067

Pollard AJ, Perrett KP, Beverley PC. Maintaining protection against invasive bacteria with protein-polysaccharide conjugate vaccines. Nat Rev Immunol 2009;9(3):2134–220.)

Snape MD1, Kelly DF, Green B, et al. Lack of serum bactericidal activity in preschool children two years after a single dose of serogroup C meningococcal polysaccharide-protein conjugate vaccine.

Pediatr Infect Dis J 2005;24:128-31.

Tuscan regional government deliberation n° 1374 (27/12/2016). Aggiornamento del calendario vaccinale della Regione Toscana e prosecuzione delle misure straordinarie di profilassi per contrastare la diffusione dell'infezione da meningococco C

Tuscan regional government deliberation n° 941 (27 September 2016). Prevenzione della diffusione del meningococco C in Toscana. Prosecuzione delle misure straordinarie di profilassi

Regional Health Agency of Tuscany. The Tuscany case. [Italian] https://www.ars.toscana.it/temi/meningite/#il-caso-toscana@a1page1 [Last accessed 6 February 2018]