Keywords
Children
Iran
Abstract
Candida spp. especially Candida albicans is considered as one of the most common cause of fungal infections. The aim of our study was to determine epidemiology of candiduria in children who were referred to an Iranian referral hospital. During May 2011 to February 2013, among 4813 urine culture positive, 209 candida spp. isolates (4.3%) was found. Forty-one percent of cadiduria infection was seen in patients between 1 month and 1 year, 24% in neonatant and 24% in patients 1 to 5 years. Cadiduria was mainly found in patients who had received more than 2 or 3 antibiotic during their hospitalization (37% and 24%, respectively). In our study, the highest frequency of cadiduria was seen in patients who had received more than 2 antibiotics and more than 3 antibiotics during their hospitalization; therefore, the strategic goals to opti- mize antimicrobial use including optimizing choice and duration of empiric therapy as well as monitoring and providing feedback regarding antibiotic resistance are recommended.References
Achkar JM, Fries BC. Candida infections of the genitourinary tract. Clin Microbiol Rev. 2010;23:253–273.
Saha R, Das SD, Kumar A, et al. Pattern of Candida isolates in hospitalized children. Indian J Pediatr. 2008;75:858–860.
Sobel JD, Fisher JF, Kauffman CA, et al. Candida urinary tract infections-epidemiology. Clin Infect Dis. 2011;52(suppl. 6):S433–S436.
Nucci M, Queiroz-Telles F, Alvarado-Matute T, et al. Epidemiology of Candidemia in Latin America: a laboratory-based survey. PloS one. 2013;8:e59373–e59373.
Kauffman CA. Candiduria. Clin Infect Dis. 2005;41(Suppl. 6):S371–S376.
Febre N, Silva V, Medeiros E, et al. Microbiological characteristics of yeasts isolated from urinary tracts of intensive care unit patients undergoing urinary catheterization. J Clin Microbiol. 1999;37:1584–1586.
Weinstein RA, Lundstrom T, Sobel J. Nosocomial candiduria: a review. Clin Infect Dis. 2001;32:1602–1607.
Richards MJ, Edwards JR, Culver DH, et al. Nosocomial infections in combined medical-surgical intensive care units in the United States. Infect Control Hosp Epidemiol. 2000;21:510–515.
Brindha S, Jayashree M, Singhi S, et al. Study of nosocomial urinary tract infections in a pediatric intensive care unit. J Trop Pediatr. 2011;57:357–362.
Pourakbari B, Rezaizadeh G, Mahmoudi S, et al. Epidemiology of nosocomial infections in pediatric patients in an Iranian referral hospital. J Prev Med Hyg. 2012;53:204–206.
Bouza E, San Juan R, Munoz P, et al. A European perspective on nosocomial urinary tract infections II. Report on incidence, clinical characteristics and outcome (ESGNI– 004 study) Clin Microbiol Infect. 2001;7:532–542.
Rivett A, Perry J, Cohen J. Urinary candidiasis: a prospective study in hospital patients. Urol Res. 1986;14:183–186.
Kauffman CA. Candiduria. Clin Infect Dis. 2005;41(Suppl. 6):S371–S376.
Jain M, Dogra V, Mishra B, et al. Candiduria in catheterized intensive care unit patients: Emerging microbiological trends. Indian J Pathol Microbiol. 2011;54:552–552.
Platt R, Polk BF, Murdock B, et al. Risk factors for nosocomial urinary tract infection. Am J Epidemiol. 1986;124:977–985.
Binelli C, Moretti M, Assis R, et al. Investigation of the possible association between nosocomial candiduria and candidaemia. Clin Microbiol Infect. 2006;12:538–543.
Phillips JR, Karlowicz MG. Prevalence of Candida species in hospital-acquired urinary tract infections in a neonatal intensive care unit. Pediatr Infect Dis J. 1997;16:190–194.
Richards MJ, Edwards JR, Culver DH, et al. Nosocomial infections in pediatric intensive care units in the United States. Pediatrics. 1999;103:e39–e39.
Alvarez-Lerma F, Nolla-Salas J, Leon C, et al. Candiduria in critically ill patients admitted to intensive care medical units. Intensive Care Med. 2003;29:1069–1076.
Passos XS, Sales WS, Maciel PJ, et al. Candida colonization in intensive care unit patients' urine. Mem Inst Oswaldo Cruz. 2005;100:925–928.
Shay AC, Miller LG. An Estimate of the Incidence of Candiduria Among Hospitalized Patients in the United States. Infection control and hospital epidemiology. 2004;25:894–895.
Hamory B, Wenzel R. Hospital-associated candiduria: predisposing factors and review of the literature. J Urol. 1978;120:444–444.
Triolo V, Gari-Toussaint M, Casagrande F, et al. Fluconazole therapy for Candida albicans urinary tract infections in infants. Pediatr Nephrol. 2002;17:550–553.
Hitchcock R, Pallett A, Hall M, et al. Urinary tract candidiasis in neonates and infants. Br J Urol. 1995;76:252–256.
Pappu LD, Purohit DM, Bradford BF, et al. Primary renal candidiasis in two preterm neonates: report of cases and review of literature on renal candidiasis in infancy. Archives of Pediatrics & Adolescent Medicine. 1984;138:923–923.
Bukhary Z. Candiduria: a review of clinical significance and management. Saudi J Kidney Dis Transpl. 2008;19:350–350.
Bochicchio GV, Joshi M, Shih D, et al. Reclassification of urinary tract infections in critically ill trauma patients: a timedependent analysis. Surg Infect. 2003;4:379–385.