Epstein-Barr Virus (EBV) acute acalculous cholecystitis in an immunocompromised adult patient: a case report of a neglected clinical presentation and a literature review over the last 30 years
Vol. 62 No. 1 (2021), History of Medicine and Ethics
Vol. 62 No. 1 (2021)

Epstein-Barr Virus (EBV) acute acalculous cholecystitis in an immunocompromised adult patient: a case report of a neglected clinical presentation and a literature review over the last 30 years

History of Medicine and Ethics
https://doi.org/10.15167/2421-4248/jpmh2021.62.1.1859
Published 2021-04-29
Niccolò Riccardi
2 Department of Infectious - Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy; StopTB Italia Onlus, Milan, Italy
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Keywords

EBV, AAC, immunosuppresed patient, cholecystitis, hepatitis

Abstract

Primary Epstein-Barr virus (EBV) infectious may present with self-limiting abdominal involvement, characterized by hepatitis with mild elevation of aminotransferases, splenomegaly, and rarely with acute acalculous cholecystitis (AAC). Usually, treatment of EBV related AAC is symptomatic, without the need for surgery. Here, we describe a severe case of AAC occurring as the first manifestation of infectious mononucleosis in a young adult woman, receiving treatment with interleukin 6 receptor (IL-6r) inhibitor for rheumatoid arthritis (RA); moreover, we performed a review of the literature on EBV-related AAC

This article has a related Erratum.

https://doi.org/10.15167/2421-4248/jpmh2021.62.1.1859
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References

2. Macsween KF, Crawford DH. Epstein-Barr virus-recent advances. Lancet Infect Dis. 2003;3(3):131-140. doi:10.1016/s1473-3099(03)00543-7

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