The "urban myth"€ of the association between neurological disorders and vaccinations
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Keywords

Vaccine
Vaccinations
Neurological disorders

Abstract

In modern society, a potentially serious adverse event attributed to a vaccination is likely to be snapped up by the media, particu- larly newspapers and television, as it appeals to the emotions of the public. The widespread news of the alleged adverse events of vaccination has helped to create the âurban myth that vac- cines cause serious neurological disorders and has boosted anti- vaccination associations. This speculation is linked to the fact that the true causes of many neurological diseases are largely unknown. The relationship between vaccinations and the onset of serious neuropsychiatric diseases is certainly one of coincidence rather than causality. This claim results from controlled studies that have excluded the association between vaccines and severe neurological diseases, therefore it can be said, with little risk of error, that the association between modern vaccinations and seri- ous neurological disorders is a true urban myth.

https://doi.org/10.15167/2421-4248/jpmh2015.56.1.467
PDF

References

Folstein S, Rutter M. Infantile autism: a genetic study of 21 twin pairs.. J Child Psychol Psychiatry 1977;18(4):297-321. Available from: http://www.scholaruniverse.com/ncbi-linkout?id=562353 PubMed PMID: 562353. doi: 10.1111/j.1469-7610.1977.tb00443.x. [Google Scholar]

Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, et al. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children.. Lancet 1998 Feb;351(9103):637-641. Available from: https://www.nlm.nih.gov/medlineplus/developmentaldisabilities.html PubMed PMID: 9500320. [Google Scholar]

Freed GL, Katz SL, Clark SJ. Safety of vaccinations. Miss America, the media, and public health.. JAMA 1996 Dec;276(23):1869-1872. Available from: http://www.scholaruniverse.com/ncbi-linkout?id=8968002 PubMed PMID: 8968002. [Google Scholar]

Kaufman M. The American anti-vaccinationists and their arguments.. Bull Hist Med 1967;41(5):463-478. Available from: https://www.nlm.nih.gov/medlineplus/immunization.html PubMed PMID: 4865041. [Google Scholar]

US. National library of Medicine . Azheimer's disease. Proceedings of . . Available from: http://www.nlm.nih.gov/medlineplus/alzheimersdisease [Google Scholar]

Nih . Alzheimer's Disease Fact Shee. Proceedings of . . Available from: http://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-fact-sheet [Google Scholar]

Szatmari P. The causes of autism spectrum disorders. BMJ 2003;326(7382):173-174. Available from: http://www.bmj.com/cgi/doi/10.1136/bmj.326.7382.173 doi: 10.1136/bmj.326.7382.173. [Google Scholar]

Liu L, Lei J, Sanders SJ, Willsey AJ, Kou Y, Cicek AE, et al. DAWN: a framework to identify autism genes and subnetworks using gene expression and genetics. Mol Autism 2014;5(1):22. Available from: http://molecularautism.biomedcentral.com/articles/10.1186/2040-2392-5-22 PubMed PMID: 24602502. doi: 10.1186/2040-2392-5-22. [Google Scholar]

Persico A, Scattoni ML. Alle origini dell' Autismo. . Available from: http://www.epicentro.iss.it/temi/vaccinazioni/originiAutismo.as [Google Scholar]

Rust RS. Multiple sclerosis, acute disseminated encephalomyelitis, and related conditions. Semin Pediatr Neurol 2000;7(2):66-90. Available from: http://www.scholaruniverse.com/ncbi-linkout?id=10914409 PubMed PMID: 10914409. doi: 10.1053/pb.2000.6693. [Google Scholar]

Tenembaum S, Chitnis T, Ness J, Hahn JS. Acute disseminated encephalomyelitis. Neurology 2007;68(suppl 2). [Google Scholar]

Dale RC. Acute disseminated encephalomyelitis. Semin Pediatr Infect Dis 2003;14(2):90-95. Available from: http://www.diseaseinfosearch.org/result/181 PubMed PMID: 12881796. doi: 10.1053/spid.2003.127225. [Google Scholar]

Sacconi S, Salviati L, Merelli E. Acute disseminated encephalomyelitis associated with hepatitis C virus infection.. Arch Neurol 2001;58(10):1679-1681. Available from: http://www.diseaseinfosearch.org/result/181 PubMed PMID: 11594929. doi: 10.1001/archneur.58.10.1679. [Google Scholar]

National Institute of Neurological Disorders and Stroke , author. NINDS encephalopathy information page. Document available at: http://www.ninds.nih.gov/disorders/encephalopathy/encephalopathy.htm. Accessed on January 23th 2015.

Weckhuysen S, Korff CM. Epilepsy: old syndromes, new genes.. Curr Neurol Neurosci Rep 2014;14(6):447. Available from: http://www.diseaseinfosearch.org/result/2593 PubMed PMID: 24740805. doi: 10.1007/s11910-014-0447-7. [Google Scholar]

Balcer LJ. Optic Neuritis. N Engl J Med 2006 Mar;354(12):1273-1280. Available from: http://www.nejm.org/doi/abs/10.1056/NEJMcp053247 doi: 10.1056/NEJMcp053247. [Google Scholar]

Beck RW, Gal RL, Bhatti MT, Brodsky MC, Buckley EG, Chrousos GA, et al. Visual function more than 10 years after optic neuritis: experience of the optic neuritis treatment trial.. Am J Ophthalmol 2004;137(1):77-83. Available from: http://www.scholaruniverse.com/ncbi-linkout?id=14700647 PubMed PMID: 14700647. doi: 10.1016/S0002-9394(03)00862-6. [Google Scholar]

Schultz SH, North SW, Shields CG. Schizophrenia: a review.. Am Fam Physician 2007 Jun;75(12):1821-1829. Available from: http://www.aafp.org/link_out?pmid=17619525 PubMed PMID: 17619525. [Google Scholar]

Mortensen PB, Pedersen CB, Westergaard T, Wohlfahrt J, Ewald H, Mors O, et al. Effects of family history and place and season of birth on the risk of schizophrenia.. N Engl J Med 1999 Feb;340(8):603-608. Available from: http://www.nejm.org/doi/abs/10.1056/NEJM199902253400803?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dwww.ncbi.nlm.nih.gov PubMed PMID: 10029644. doi: 10.1056/NEJM199902253400803. [Google Scholar]

Wahlberg K, Wynne LC, Hakko H, Läksy K, Moring J, Miettunen J, et al. Interaction of genetic risk and adoptive parent communication deviance: longitudinal prediction of adoptee psychiatric disorders. Psychol Med 2004;34(8):1531-1541. Available from: http://www.scholaruniverse.com/ncbi-linkout?id=15724883 PubMed PMID: 15724883. doi: 10.1017/S0033291704002661. [Google Scholar]

Lewis DA, Lieberman JA. Catching up on schizophrenia: natural history and neurobiology.. Neuron 2000;28(2):325-334. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0896-6273(00)00111-2 PubMed PMID: 11144342. doi: 10.1016/S0896-6273(00)00111-2. [Google Scholar]

National Institute of Neurological Disorders and Stroke , author. Transverse myelitis fact sheet. Available at: http://www.ninds.nih.gov/disorders/transversemyelitis/detail_transversemyelitis.htm. Accessed on January 23th 2015.

CNN "Larry King Live Transcript". CNN. 15 December 2005. Available at: http://transcripts.cnn.com/TRANSCRIPTS/0512/15/lkl.01.html, accessed on 10th February 12 2015.

Russ S. According to the media, it's flu season again. Alzheimer's anyone? Available at: http://www.doctorschierling.com/blog/its-flu-season-again-alzheimers-anyone. Accessed on February 12th, 2015.

Verreault R, Laurin D, Lindsay J, De Serres G. Past exposure to vaccines and subsequent risk of Alzheimer's disease.. CMAJ 2001 Nov;165(11):1495-1498. Available from: http://www.cmaj.ca/cgi/pmidlookup?view=long&pmid=11762573 PubMed PMID: 11762573. [Google Scholar]

Godlee F, Smith J, Marcovitch H. Wakefield's article linking MMR vaccine and autism was fraudulent. BMJ 2011;342. [Google Scholar]

Black C, Kaye JA, Jick H. Relation of childhood gastrointestinal disorders to autism: nested casecontrol study using data from the UK General Practice Research Database. BMJ 2002;325(7361):419-421. Available from: http://www.bmj.com/cgi/doi/10.1136/bmj.325.7361.419 doi: 10.1136/bmj.325.7361.419. [Google Scholar]

Taylor B, Miller E, Lingam R, Andrews N, Simmons A, Stowe J. Measles, mumps, and rubella vaccination and bowel problems or developmental regression in children with autism: population study. BMJ 2002;324(7334):393-396. Available from: http://europepmc.org/abstract/MED/11850369 PubMed PMID: 11850369. doi: 10.1136/bmj.324.7334.393. [Google Scholar]

Madsen KM, Hviid A, Vestergaard M, Schendel D, Wohlfahrt J, Thorsen P, et al. A Population-Based Study of Measles, Mumps, and Rubella Vaccination and Autism. N Engl J Med 2002 Nov;347(19):1477-1482. Available from: http://www.nejm.org/doi/abs/10.1056/NEJMoa021134 doi: 10.1056/NEJMoa021134. [Google Scholar]

Honda H, Shimizu Y, Rutter M. No effect of MMR withdrawal on the incidence of autism: a total population study. J Child Psychol Psychiatry 2005;46(6):572-579. Available from: http://www.diseaseinfosearch.org/result/673 PubMed PMID: 15877763. doi: 10.1111/j.1469-7610.2005.01425.x. [Google Scholar]

IOM (Institute of Medicine) , author . Adverse effects of vaccines: Evidence and causality. Washington, DC: The National Academies Press; 2011. [Google Scholar]

Plotkin SA, Orenstein WA, Offit PA. Vaccines. 6th edition. Philadelphia: Elsevier Health Sciences; 2012. [Google Scholar]

Albano A, Salvaggio L. Manuale di Igiene. 2nd edition. Padova: Piccin; 1987. [Google Scholar]

Duclos P, Ward BJ. Measles vaccines: a review of adverse events. Drug safety 1998;6(6):435-454. Available from: http://link.springer.com/10.2165/00002018-199819060-00002 doi: 10.2165/00002018-199819060-00002. [Google Scholar]

Bino S, Kakarriqi E, Xibinaku M, Ion-Nedelcu N, Bukli M, Emiroglu N, et al. Measles-rubella mass immunization campaign in Albania, November 2000.. J Infect Dis 2003 May;187 Suppl 1(Suppl 1). Available from: http://www.jid.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=12721917 PubMed PMID: 12721917. doi: 10.1086/368055. [Google Scholar]

Makela A, Nuorti JP, Peltola H. Neurologic disorders after measles-mumps-rubella vaccination.. Pediatrics 2002;110(5):957-963. Available from: http://www.diseaseinfosearch.org/result/4535 PubMed PMID: 12415036. doi: 10.1542/peds.110.5.957. [Google Scholar]

Ray P, Hayward J, Michelson D, Lewis E, Schwalbe J, Black S, et al. Encephalopathy after whole-cell pertussis or measles vaccination: lack of evidence for a causal association in a retrospective case-control study.. Pediatr Infect Dis J 2006;25(9):768-773. Available from: http://www.diseaseinfosearch.org/result/4535 PubMed PMID: 16940831. doi: 10.1097/01.inf.0000234067.84848.e1. [Google Scholar]

The Health Boards Executive. The MMR discussion pack an information guide for health professionals and parents. Produced by the National Disease Surveillance Centre and the Department of Public Health, Southern Health Board. Available at https://www.hpsc.ie/A-Z/VaccinePreventable/Measles/Publications/File,1242,en.pdf Accessed on 20th February 2015.

Shoamanesh A, Traboulsee A. Acute disseminated encephalomyelitis following influenza vaccination. Vaccine 2011;29(46):8182-8185. Available from: http://www.diseaseinfosearch.org/result/181 PubMed PMID: 21925561. doi: 10.1016/j.vaccine.2011.08.103. [Google Scholar]

Machicado JD, Bhagya-Rao B, Davogustto G, McKelvy BJ. Acute Disseminated Encephalomyelitis following Seasonal Influenza Vaccination in an Elderly Patient. Clinical and Vaccine Immunology 2013;20(9):1485-1486. Available from: http://cvi.asm.org/cgi/doi/10.1128/CVI.00307-13 doi: 10.1128/CVI.00307-13. [Google Scholar]

France EK, Glanz JM, Xu S, Davis RL, Black SB, Shinefield HR, et al. Safety of the trivalent inactivated influenza vaccine among children: a population-based study.. Arch Pediatr Adolesc Med 2004;158(11):1031-1036. Available from: http://www.scholaruniverse.com/ncbi-linkout?id=15520339 PubMed PMID: 15520339. doi: 10.1001/archpedi.158.11.1031. [Google Scholar]

Goodman MJ, Nordin JD, Harper P, Defor T, Zhou X. The safety of trivalent influenza vaccine among healthy children 6 to 24 months of age.. Pediatrics 2006;117(5). PubMed PMID: 16651286. doi: 10.1542/peds.2005-2234. [Google Scholar]

Hambidge SJ, Glanz JM, France EK, McClure D, Xu S, Yamasaki K, et al. Safety of Trivalent Inactivated Influenza Vaccine in Children 6 to 23 Months Old. JAMA 2006 Oct;296(16):1990. Available from: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.296.16.1990 doi: 10.1001/jama.296.16.1990. [Google Scholar]

Lee GM, Greene SK, Weintraub ES, et al. Vaccine safety datalink project. H1N1 and seasonal influenza vaccine safety in the vaccine safety datalink project. Am J Prev Med 2011;41(2):121-128. Available from: http://www.scholaruniverse.com/ncbi-linkout?id=21767718 PubMed PMID: 21767718. doi: 10.1016/j.amepre.2011.04.004. [Google Scholar]

Howson CP, Howe CJ, Fineberg HV. Institute of Medicine (US) Committee to Review the Adverse Consequences of Pertussis and Rubella Vaccines , author. Adverse effects of pertussis and rubella vaccines: A report of the Committee to Review the Adverse Consequences of Pertussis and Rubella Vaccines. Washington (DC: National Academies Press; 1991. [Google Scholar]

Stratton K, Gable A, Dhetty P, et al. Immunization Safety Review Measles-Mumps-Rubella Vaccine and Autism. Insitute of Medicine. National Academy Press; 2001.

Greco D. Case-control study on encephalopathy associated with diphtheria-tetanus immunization in Campania, Italy. Bulletin of The World Health Organization 1985;63(5):919-925. Available from: http://europepmc.org/abstract/MED/3879203 PubMed PMID: 3879203. [Google Scholar]

Crovari P, Gasparini R, D' Aste E, Culotta C, Romano L. [Case-control study on the association of neurological syndromes and compulsory vaccinations in Liguria during the period January 1980-February 1983].. Boll Ist Sieroter Milan 1984 May;63(2):118-124. Available from: https://www.nlm.nih.gov/medlineplus/coma.html PubMed PMID: 6466452. [Google Scholar]

Yih WK, Nordin JD, Kulldorff M, Lewis E, Lieu TA, Shi P, et al. An assessment of the safety of adolescent and adult tetanus-diphtheria-acellular pertussis (Tdap) vaccine, using active surveillance for adverse events in the Vaccine Safety Datalink.. Vaccine 2009;27(32):4257-4262. Available from: http://www.scholaruniverse.com/ncbi-linkout?id=19486957 PubMed PMID: 19486957. doi: 10.1016/j.vaccine.2009.05.036. [Google Scholar]

Ray P, Hayward J, Michelson D, Lewis E, Schwalbe J, Black S, et al. Encephalopathy after whole-cell pertussis or measles vaccination: lack of evidence for a causal association in a retrospective case-control study.. Pediatr Infect Dis J 2006;25(9):768-773. Available from: http://www.diseaseinfosearch.org/result/4535 PubMed PMID: 16940831. doi: 10.1097/01.inf.0000234067.84848.e1. [Google Scholar]

Ward KN, Bryant NJ, Andrews NJ, Bowley JS, Ohrling A, Verity CM, et al. Risk of serious neurologic disease after immunization of young children in Britain and Ireland.. Pediatrics 2007;120(2):314-321. Available from: https://www.nlm.nih.gov/medlineplus/immunization.html PubMed PMID: 17671057. doi: 10.1542/peds.2006-3743. [Google Scholar]

Tregnaghi M, Lopez P, Stamboulian D, Graña G, Odrljin T, Bedell L, et al. Immunogenicity and safety of a quadrivalent meningococcal polysaccharide CRM conjugate vaccine in infants and toddlers. Int J Infect Dis 2014;26:22-30. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1201-9712(14)01484-2 PubMed PMID: 24980467. doi: 10.1016/j.ijid.2014.03.1390. [Google Scholar]

Ilyina N, Kharit S, Namazova-Baranova L, Asatryan A, Benashvili M, Tkhostova E, et al. Safety and immunogenicity of meningococcal ACWY CRM197-conjugate vaccine in children, adolescents and adults in Russia.. Hum Vaccin Immunother 2014;10(8):2471-2481. Available from: https://www.nlm.nih.gov/medlineplus/meningococcalinfections.html PubMed PMID: 25424958. doi: 10.4161/hv.29571. [Google Scholar]

Lee HJ, Chung M, Kim WJ, Hong YJ, Choi KM, Lee J, et al. Immunogenicity and safety of a novel quadrivalent meningococcal conjugate vaccine (MenACWY-CRM) in healthy Korean adolescents and adults. Int J Infect Dis 2014;28:204-210. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1201-9712(14)01568-9 PubMed PMID: 25316331. doi: 10.1016/j.ijid.2014.06.008. [Google Scholar]

Herroelen L, de Keyser J, Ebinger G. Central-nervous-system demyelination after immunisation with recombinant hepatitis B vaccine. Lancet 1991;338(8776):1174-1175. Available from: http://www.scholaruniverse.com/ncbi-linkout?id=1682594 PubMed PMID: 1682594. doi: 10.1016/0140-6736(91)92034-Y. [Google Scholar]

Ascherio A, Zhang SM, Hernán MA, Olek MJ, Coplan PM, Brodovicz K, et al. Hepatitis B vaccination and the risk of multiple sclerosis.. N Engl J Med 2001;344(5):327-332. Available from: http://www.nejm.org/doi/abs/10.1056/NEJM200102013440502?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dwww.ncbi.nlm.nih.gov PubMed PMID: 11172163. doi: 10.1056/NEJM200102013440502. [Google Scholar]

Institut de Veille Sanitaire , author. La coverture vaccinale en France. Available at: http://www.invs.sante.fr/Espace-presse/Communiques-de-presse/2013/La-couverture-vaccinale-en-France. Accessed on 25 January 2015.

Ministero della salute. Vaccinazioni dell'età pediatrica. Anno 2013. Document available at: http://www.salute.gov.it/imgs/C_17_pagineAree_811_listaFile_itemName_17_file.pdf; accessed on 25th January 2015.

Kulenkampff M, Schwartzman JS, Wilson J. Neurological complications of pertussis inoculation. Arch Dis Child 1974;49(1):46-49. Available from: http://europepmc.org/abstract/MED/4818092 PubMed PMID: 4818092. doi: 10.1136/adc.49.1.46. [Google Scholar]

Koplan JP, Hinman AH. Decision analysis, public policy, and pertussis: are they compatible. Medical Decision Making 1987;7:72. [Google Scholar]

Coulter HL, Fisher BL. DTP: A shot in the dark. San Diego: Harcourt Brace Jovanovich; 1985. [Google Scholar]

Howson CP, Howe CJ, Fineberg HV. Institute of Medicine (US) Committee to Review the Adverse Consequences of Pertussis and Rubella Vaccines , author. Consequences of Pertussis and Rubella Vaccines. Washington (DC): National. Washington (DC: Academies Press; 1991. [Google Scholar]

Farrington P, Pugh S, Colville A, Flower A, Nash J, Morgan-Capner P, et al. A new method for active surveillance of adverse events from diphtheria/tetanus/pertussis and measles/mumps/rubella vaccines. Lancet 1995;345(8949):567-569. Available from: http://www.diseaseinfosearch.org/result/2292 PubMed PMID: 7619183. doi: 10.1016/S0140-6736(95)90471-9. [Google Scholar]

Barlow WE, Davis RL, Glasser JW, Rhodes PH, Thompson RS, Mullooly JP, et al. The risk of seizures after receipt of whole-cell pertussis or measles, mumps, and rubella vaccine.. N Engl J Med 2001 Aug;345(9):656-661. Available from: http://www.nejm.org/doi/abs/10.1056/NEJMoa003077?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dwww.ncbi.nlm.nih.gov PubMed PMID: 11547719. doi: 10.1056/NEJMoa003077. [Google Scholar]

Miller E, Andrews N, Stowe J, Grant A, Waight P, Taylor B. Risks of convulsion and aseptic meningitis following measles-mumps-rubella vaccination in the United Kingdom.. Am J Epidemiol 2007 Jan;165(6):704-709. Available from: http://aje.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17204517 PubMed PMID: 17204517. doi: 10.1093/aje/kwk045. [Google Scholar]

Vestergaard M, Hviid A, Madsen KM, Wohlfahrt J, Thorsen P, Schendel D, et al. MMR vaccination and febrile seizures: evaluation of susceptible subgroups and long-term prognosis.. JAMA 2004 Jul;292(3):351-357. Available from: http://www.scholaruniverse.com/ncbi-linkout?id=15265850 PubMed PMID: 15265850. doi: 10.1001/jama.292.3.351. [Google Scholar]

Weckhuysen S, Korff CM. Epilepsy: old syndromes, new genes.. Curr Neurol Neurosci Rep 2014;14(6):447. Available from: http://www.diseaseinfosearch.org/result/2593 PubMed PMID: 24740805. doi: 10.1007/s11910-014-0447-7. [Google Scholar]

Reyes IS, Hsieh DT, Laux LC, Wilfong AA. Alleged cases of vaccine encephalopathy rediagnosed years later as Dravet syndrome. Pediatrics 2011 Aug;128(3). Available from: http://www.ncbi.nlm.nih.gov/pubmed/21844054 PubMed PMID: 21844054. doi: 10.1542/peds.2010-0887. [Google Scholar]

Stefano F, Verstraeten T, Jackson LA, et al. Vaccinations and risk of central nervous system demyelinating diseases in adults. Arch Neurol 2003;60(4):504. Available from: http://archneur.jamanetwork.com/article.aspx?doi=10.1001/archneur.60.4.504 doi: 10.1001/archneur.60.4.504. [Google Scholar]

Cl RR, Dreizin IJ. Bilateral optic neuropathy associated with influenza vaccination. Journal of Neuro-Ophthalmology 1996;16:182. [Google Scholar]

Vilain S, Waterschoot MP, Mavroudakis N. Encephalomyelitis and bilateral optic perineuritis after influenza vaccination. Bulletin de la Societe Belge d Ophtalmologie 2000;277(277):71-73. Available from: http://www.diseaseinfosearch.org/result/2523 PubMed PMID: 11126677. [Google Scholar]

Huynh W, Cordato DJ, Kehdi E, et al. Post-vaccination encephalomyelitis: Literature review and illustrative case. Post-vaccination encephalomyelitis: Literature review and illustrative case 2008;15(12):1315-1322. Available from: http://www.diseaseinfosearch.org/result/2523 PubMed PMID: 18976924. doi: 10.1016/j.jocn.2008.05.002. [Google Scholar]

Tan FU, Akarsu C, Gullu R, Kansu T. Bilateral optic neuritis after influenza vaccination. Neuro-Ophthalmology 2010;34(2):115-117. Available from: http://www.tandfonline.com/doi/full/10.3109/01658101003725847 doi: 10.3109/01658101003725847. [Google Scholar]

Vellozzi C, Burwen DR, Dobardzic A, Ball R, Walton K, Haber P. Safety of trivalent inactivated influenza vaccines in adults: background for pandemic influenza vaccine safety monitoring.. Vaccine 2009;27(15):2114-2120. Available from: https://www.nlm.nih.gov/medlineplus/flu.html PubMed PMID: 19356614. doi: 10.1016/j.vaccine.2009.01.125. [Google Scholar]

Payne DC, Rose Jr CE, Kerrison J, Aranas A, Duderstadt S, McNeil MM. Anthrax vaccination and risk of optic neuritis in the United States military, 1998-2003.. Arch Neurol 2006;63(6):871-875. Available from: http://www.diseaseinfosearch.org/result/515 PubMed PMID: 16769869. doi: 10.1001/archneur.63.6.871. [Google Scholar]

Liang X, Li L, Liu D, Li K, Wu W, Zhu B, et al. Safety of Influenza A (H1N1) Vaccine in Postmarketing Surveillance in China. N Engl J Med 2011 Feb;364(7):638-647. Available from: http://www.nejm.org/doi/abs/10.1056/NEJMoa1008553 doi: 10.1056/NEJMoa1008553. [Google Scholar]

Williams SE, Pahud BA, Vellozzi C, Donofrio PD, Dekker CL, Halsey N, et al. Causality assessment of serious neurologic adverse events following 2009 H1N1 vaccination. Vaccine 2011;29(46):8302-8308. Available from: https://www.nlm.nih.gov/medlineplus/immunization.html PubMed PMID: 21893148. doi: 10.1016/j.vaccine.2011.08.093. [Google Scholar]

Albitar S, Bourgeon B, Genin R, Fen-Chong M, N'Guyen P, Serveaux M, et al. Bilateral retrobulbar optic neuritis with hepatitis B vaccination. Nephrology Dialysis Transplantation 1997 Oct;12(10):2169-2170. Available from: http://ndt.oxfordjournals.org/cgi/doi/10.1093/ndt/12.10.2169 doi: 10.1093/ndt/12.10.2169. [Google Scholar]

Voigt U, Baum U, Behrendt W, et al. Neuritis of the optic nerve after vaccinations against hepatitis A, hepatitis B and yellow fever. Klinische Monatsblatter fur Augenheilkunde 2001;218(10):688-690. Available from: http://www.diseaseinfosearch.org/result/3332 PubMed PMID: 11706386. doi: 10.1055/s-2001-18392. [Google Scholar]

Erguven M, Guven S, Akyuz U, Bilgiç O, Laloglu F. Optic Neuritis Following Hepatitis B Vaccination in a 9-year-old Girl. Journal of the Chinese Medical Association 2009;72(11):594-597. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1726490109704356 doi: 10.1016/S1726-4901(09)70435-6. [Google Scholar]

Roussat B, Gohier P, Doummar D, Iba-Zizen MT, Barbat V, Jarry D, et al. [Acute optic neuritis in children: clinical features and treatment. A study of 28 eyes in 20 children].. J Fr Ophtalmol 2001;24(1):36-44. Available from: http://www.masson.fr/masson/MDOI-JFO-01-2001-24-1-0181-5512-101019-ART5 PubMed PMID: 11240469. [Google Scholar]

Quast U, Hennessen W, Widmark RM. Mono- and polyneuritis after tetanus vaccination (1970--1977).. Dev Biol Stand 1979;43:25-32. Available from: http://www.diseaseinfosearch.org/result/5845 PubMed PMID: 520671. [Google Scholar]

Blaylock RL. Immunology primer for neurosurgeons and neurologists part 2: Innate brain immunity.. Surg Neurol Int 2013;4(1):118. Available from: http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2013;volume=4;issue=1;spage=118;epage=118;aulast=Blaylock PubMed PMID: 24083053. doi: 10.4103/2152-7806.118349. [Google Scholar]

Blaylock RL. The danger of excessive vaccination during brain development. Available at http://www.vaccineinfo4parents.co.uk/PDF/Mercola005.pdf. Accessed on 7th February 2015.

Miranda LR. Schizophrenia and Autism are the effects of vaccine stimulation in unborn children. Available at: http://realagenda.com/2014/04/14/schizophrenia-and-autism-are-the-effects-of-vaccine-stimulation-in-unborn-children/ Accessed on 7th February 2015.

Patterson H. Pregnancy, Immunity, Schizophrenia, and Autism. Engineering & Science 2006;3:10. [Google Scholar]

Short SJ, Lubach GR, Karasin AI, Olsen CW, Styner M, Knickmeyer RC, et al. Maternal influenza infection during pregnancy impacts postnatal brain development in the rhesus monkey.. Biol Psychiatry 2010;67(10):965-973. Available from: http://europepmc.org/abstract/MED/20079486 PubMed PMID: 20079486. doi: 10.1016/j.biopsych.2009.11.026. [Google Scholar]

Mednick SA, Machon RA, Huttunen MO, et al. Adult schizophrenia following prenatal exposure to an influenza epidemic. Arch Gen Psychiatry 1988;45(2):189. Available from: http://archpsyc.jamanetwork.com/article.aspx?doi=10.1001/archpsyc.1988.01800260109013 doi: 10.1001/archpsyc.1988.01800260109013. [Google Scholar]

Byrne M, Agerbo E, Bennedsen B, Eaton WW, Mortensen PB. Obstetric conditions and risk of first admission with schizophrenia: a Danish national register based study.. Schizophr Res 2007;97(1-3):51-59. Available from: http://www.scholaruniverse.com/ncbi-linkout?id=17764905 PubMed PMID: 17764905. doi: 10.1016/j.schres.2007.07.018. [Google Scholar]

CDC , author . Prevention and control of seasonal influenza with vaccines. Recommendations of the Advisory Committee on Immunization Practices-United States, 2013-2014. MMWR 2013;62(RR-07):1-43. Available from: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr6207a1.htm PubMed PMID: 24048214. [Google Scholar]

Cizman M, Pokorn M, Osredkar D. Re: transverse myelitis after measles and rubella vaccination. J Paediatr Child Health 2005;41(8):460-460. Available from: http://doi.wiley.com/10.1111/j.1440-1754.2005.00673.x doi: 10.1111/j.1440-1754.2005.00673.x. [Google Scholar]

Joyce KA, Rees JE. Transverse myelitis after measles, mumps, and rubella vaccine.. BMJ 1995 Aug;311(7002):422-422. Available from: http://europepmc.org/abstract/MED/7640590 PubMed PMID: 7640590. doi: 10.1136/bmj.311.7002.422a. [Google Scholar]

Lim S, Park SM, Choi HS, Kim DK, Kim HB, Yang BG, et al. Transverse myelitis after measles and rubella vaccination. J Paediatr Child Health 2004;40(9-10):583-584. Available from: http://doi.wiley.com/10.1111/j.1440-1754.2004.00470.x PubMed PMID: 15367159. doi: 10.1111/j.1440-1754.2004.00470.x. [Google Scholar]

LaRovere KL, Raju, G. Praveen, , Gorman MP. Postvaricella Acute Transverse Myelitis in a Previously Vaccinated Child. Pediatric Neurology 2008;38(5):370-372. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0887899408000660 doi: 10.1016/j.pediatrneurol.2008.02.002. [Google Scholar]

Bakshi R, Mazziotta JC. Acute transverse myelitis after influenza vaccination: magnetic resonance imaging findings.. J Neuroimaging 1996;6(4):248-250. Available from: http://www.scholaruniverse.com/ncbi-linkout?id=8903080 PubMed PMID: 8903080. doi: 10.1111/jon199664248. [Google Scholar]

Nakamura N, Nokura K, Zettsu T, et al. Neurologic complications associated with influenza vaccination: two adult cases. Internal Medicine 2003;42(2):191-194. Available from: http://joi.jlc.jst.go.jp/JST.Journalarchive/internalmedicine1992/42.191?from=PubMed PubMed PMID: 12636241. doi: 10.2169/internalmedicine.42.191. [Google Scholar]

Tartaglino LM, Heiman-Patterson T, Friedman DP, et al. MR imaging in a case of postvaccination myelitis. AJNR Am J Neuroradiol 1995;16:581. [Google Scholar]

Government of Western Australia – Department of Health , author. Vaccine side effects fact sheet, November 2005. Available at: http://www.public.health.wa.gov.au/cproot/432/2/fs%20vaccine%20side%20effects.pdf. Accessed on February 21sd 2015.

Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin SE. Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation.. Clin Exp Immunol 2007;147(2):227-235. Available from: http://dx.doi.org/10.1111/j.1365-2249.2006.03261.x PubMed PMID: 17223962. doi: 10.1111/j.1365-2249.2006.03261.x. [Google Scholar]