Abstract
At the end of 1980, Michael Gottlieb, a researcher at the University of California, was conducting a clinical study on deficiencies of the immune system when he heard of the case of a young man with a rare form of pneumonia due to Pneumocystis carinii (now known as Pneumocystis jirovecii), a protozoon that usually affects only people with a weakened immune system. In the following months, Gottlieb discovered further cases of patients with Pneumocystis carinii pneumonia, oral candidiasis and a very low level of T lymphocytes. All were male and active homosexuals. In reality the infection had already manifested itself in previous years but had always been mistaken for something else. HIV probably originated from a virus found in chimpanzees and began infecting humans in the first half of the 20th century. It probably emerged when members of the Bantu tribe, who lived in the forests of central Africa, consumed chimpanzee meat infected with a virus called simian immunodeficiency virus (SIV). This may have caused a so-called spillover from chimpanzees to humans.
References
Walzer PD, Perl DP, Krogstad DJ, Rawson PG, Schultz MG. Pneumocystis carinii pneumonia in the United States. Epidemiologic, diagnostic, and clinical features. Ann Intern Med. 1974 Jan;80(1):83-93. doi: 10.7326/0003-4819-80-1-83.
Drew WL, Mintz L, Miner RC, Sands M, Ketterer B. Prevalence of cytomegalovirus infection in homosexual men. J Infect Dis. 1981 Feb;143(2):188-92. doi: 10.1093/infdis/143.2.188. PMID: 6260871.
Rinaldo CR Jr, Black PH, Hirsch MS. Interaction of cytomegalovirus with leukocytes from patients with mononucleosis due to cytomegalovirus. J Infect Dis. 1977 Nov;136(5):667-78. doi: 10.1093/infdis/136.5.667. PMID: 199675.
Faria NR, Rambaut A, Suchard MA, Baele G, Bedford T, Ward MJ, Tatem AJ, Sousa JD, Arinaminpathy N, Pépin J, Posada D, Peeters M, Pybus OG, Lemey P. HIV epidemiology. The early spread and epidemic ignition of HIV-1 in human populations. Science. 2014 Oct 3;346(6205):56-61. doi: 10.1126/science.1256739.
Quammen D. Spillover: Animal Infections and the Next Human Pandemic. The Bodley Head Ltd, 2012.
Zhu T, Korber BT, Nahmias AJ, Hooper E, Sharp PM, Ho DD. An African HIV-1 sequence from 1959 and implications for the origin of the epidemic. Nature. 1998 Feb 5;391(6667):594-7. doi: 10.1038/35400.
Junqueira DM, de Medeiros RM, Matte MC, Araújo LA, Chies JA, Ashton-Prolla P, Almeida SE. Reviewing the history of HIV-1: spread of subtype B in the Americas. PLoS One. 2011;6(11):e27489. doi: 10.1371/journal.pone.0027489.
Gilbert MT, Rambaut A, Wlasiuk G, Spira TJ, Pitchenik AE, Worobey M. The emergence of HIV/AIDS in the Americas and beyond. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18566-70. doi: 10.1073/pnas.0705329104.
Centers for Disease Control and Prevention (CDC). Pneumocystis Pneumonia - Los Angeles. MMWR Morbidity and Mortality Weekly Report, June 5, 1981 / 30(21);1-3. Available at: https://www.cdc.gov/mmwr/preview/mmwrhtml/june_5.htm (Accessed on: 28/08/2025).
Orsini D, Sartini M, Spagnolo AM, Cristina ML, Martini M. Mpox: "the stigma is as dangerous as the virus". Historical, social, ethical issues and future forthcoming. J Prev Med Hyg. 2024 Jan 1;64(4):E398-E404. doi: 10.15167/2421-4248/jpmh2023.64.4.3144.
Centers for Disease Control and Prevention (CDC). Epidemiologic Notes and Reports Update on Kaposi's Sarcoma and Opportunistic Infections in Previously Healthy Persons - United States. MMWR Morbidity and Mortality Weekly Report, June 11, 1982 / 31(22);294,300-1. Available at: https://www.cdc.gov/mmwr/preview/mmwrhtml/00001111.htm (Accessed on: 28/08/2025).
Brennan RO, Durack DT. Gay compromise syndrome. Lancet. 1981 Dec 12;2(8259):1338-9. doi: 10.1016/s0140-6736(81)91352-0.
Gallo R.C., Montagnier L. The Discovery of HIV as the Cause of AIDS. N Engl J Med 2003;349:2283-2285 [DOI: 10.1056/NEJMp038194]
Barré-Sinoussi F, Chermann J.C., Rey F, Nugeyre M.T., Chamaret S, Gruest J, Dauguet C, Axler-Blin C, Vézinet-Brun F, Rouzioux C, Rozenbaum W, Montagnier L. Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS). Science. 1983 May 20;220(4599):868-71. doi: 10.1126/science.6189183.
Gallo R.C., Sarin P.S., Gelmann E.P., Robert-Guroff M, Richardson E, Kalyanaraman V.S, Mann D, Sidhu G.D, Stahl R.E, Zolla-Pazner S, Leibowitch J, Popovic M Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS). Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS). Science. 1983 May 20;220(4599):865-7. doi: 10.1126/science.6601823.
Gelmann EP, Popovic M, Blayney D, Masur H, Sidhu G, Stahl RE, Gallo RC. Proviral DNA of a retrovirus, human T-cell leukemia virus, in two patients with AIDS. Science. 1983 May 20;220(4599):862-5. doi: 10.1126/science.6601822.
Shaw GM, Hahn BH, Arya SK, Groopman JE, Gallo RC, Wong-Staal F. Molecular characterization of human T-cell leukemia (lymphotropic) virus type III in the acquired immune deficiency syndrome. Science. 1984 Dec 7;226(4679):1165-71. doi: 10.1126/science.6095449.
Essex M, McLane MF, Lee TH, Falk L, Howe CW, Mullins JI, Cabradilla C, Francis DP. Antibodies to cell membrane antigens associated with human T-cell leukemia virus in patients with AIDS. Science. 1983 May 20;220(4599):859-62. doi: 10.1126/science.6342136.
The Nobel Prize in Physiology or Medicine 2008 was divided, one half awarded to Harald zur Hausen "for his discovery of human papilloma viruses causing cervical cancer", the other half jointly to Françoise Barré-Sinoussi and Luc Montagnier "for their discovery of human immunodeficiency virus". Available at: https://www.nobelprize.org/prizes/medicine/2008/summary/ (Accessed on: 28/08/2025).
World Health Organization – WHO. HIV and AIDS. 15 July 2025. Available at: https://www.who.int/news-room/fact-sheets/detail/hiv-aids (Accessed on: 16/08/2025).
Renfro P.M. The Life and Death of Ryan White: AIDS and Inequality in America. UNC Press, October 2024.
Circolare 17.7.1985 Direzione generale del Servizio di igiene pubblica, Prot. 400.2/30.H/2087. Infezioni da LAV/HTLV- Misure di sorveglianza e profilassi.
Legge 29 dicembre 1987, n. 531 Conversione in legge, con modificazioni, del Decreto-legge 30 ottobre 1987, n. 443, recante disposizioni urgenti in materia sanitaria.
World Health Organization - WHO. The acquired immunodeficiency syndrome (AIDS): memorandum from a WHO meeting. Bull World Health Organ. 1985;63(4):667-72. PMID: 3878739; PMCID: PMC2536365.
Centers for Disease Control and Prevention (CDC) Pneumocystis Pneumonia - Los Angeles. MMWR Morbidity and Mortality Weekly Report, December 6, 1985 / 34(48);721-6,731-2. Available at: https://www.cdc.gov/mmwr/preview/mmwrhtml/00033122.htm (Accessed on: 29/08/2025).
A Timeline of HIV and AIDS. Available at: https://www.hiv.gov/hiv-basics/overview/history/hiv-and-aids-timeline#year-1981 (Accessed on: 28/08/2025).
Alonzo AA, Reynolds NR. Stigma, HIV and AIDS: an exploration and elaboration of a stigma trajectory. Soc Sci Med. 1995 Aug;41(3):303-15. doi: 10.1016/0277-9536(94)00384-6. PMID: 7481925.
Nyblade L, Mingkwan P, Stockton MA. Stigma reduction: an essential ingredient to ending AIDS by 2030. Lancet HIV. 2021 Feb;8(2):e106-e113. doi: 10.1016/S2352-3018(20)30309-X.
Asrina A, Ikhtiar M, Idris FP, Adam A, Alim A. Community stigma and discrimination against the incidence of HIV and AIDS. J Med Life. 2023 Sep;16(9):1327-1334. doi: 10.25122/jml-2023-0171.
World Health Organization - WHO. Information sheet HIV statistics, globally and by WHO region, 2025. Available at: https://cdn.who.int/media/docs/default-source/hq-hiv-hepatitis-and-stis-library/who-ias-hiv-statistics_2025-new.pdf (Accessed on: 29/08/2025).
UnAIDS. Global HIV & AIDS statistics - Fact sheet. Available at: https://www.unaids.org/en/resources/fact-sheet (Accessed on: 29/08/2025).
World Health Organization - WHO. FDA approval of injectable lenacapavir marks progress for HIV prevention. 19 June 2025. Available at: https://www.who.int/news/item/19-06-2025-fda-approval-of-injectable-lenacapavir-marks-progress-for-hiv-prevention (Accessed on: 29/08/2025).
World Health Organization - WHO. Guidelines on lenacapavir for HIV prevention and testing strategies for long-acting injectable pre-exposure prophylaxis. 14 July 2025. Available at: https://www.who.int/publications/i/item/9789240111608 (Accessed on: 29/08/2025).