High prevalence and associated factors of Mycoplasma pneumoniae infection in children under 5 years with atypical pneumonia
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Keywords

risk factors
mycoplasmapneumoniae
atypical pneumonia

Abstract

Objectives: To identify the prevalence of Mycoplasma pneumoniae infection and association with age and gender among children aged from 2 months to 5 years, hospitalized with atypical pneumonia in Vietnam.

Methods: A retrospective descriptive study was performed using data collected from the electronic medical records. M. pneumoniae infection was determined by the IgM serology test.

Results: 1,296 pediatric patients were included. The majority of children with atypical pneumonia were aged 12 months or older, with only 3.6% of cases being under 12 months of age. Male patients accounted for 58.7% of the cases. Prevalence of M. pneumoniae infection was 47.3%. Compared to children under 12 months of age, those aged 12 to under 36 months had a 10 times higher risk of M. pneumoniae infection, with OR = 9.44, 95%CI = [2.90 – 30.77]. Compared to children under 12 months of age, those aged 36 months to under 5 years had a 20 times higher risk of M. pneumoniae infection, with OR = 20.19, 95% CI = [6.20 – 65.69]. Compared to female children, male children had nearly twice the lower risk of M. pneumoniae infection, with OR = 0.62, 95% CI = [0.50 – 0.78].

Conclusion: Our study provides additional evidence on the role of M. pneumoniae in atypical pneumonia in children, while also highlighting significant risk factors for M. pneumoniae infection.

https://doi.org/10.15167/2421-4248/jpmh2025.66.3.3574
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References

Huong PLT, Hien PT, Lan NTP, Binh TQ, Tuan DM, Anh DD. First report on prevalence and risk factors of severe atypical pneumonia in Vietnamese children aged 1-15 years. BMC Public Health 2014;14:1304. https://doi.org/10.1186/1471-2458-14-1304.

Wertheim HFL, Nadjm B, Thomas S, Agustiningsih null, Malik S, Nguyen DNT, et al. Viral and atypical bacterial aetiologies of infection in hospitalised patients admitted with clinical suspicion of influenza in Thailand, Vietnam and Indonesia. Influenza Other Respir Viruses 2015;9:315–22. https://doi.org/10.1111/irv.12326.

Waites KB, Talkington DF. Mycoplasma pneumoniae and Its Role as a Human Pathogen. Clin Microbiol Rev 2004;17:697–728. https://doi.org/10.1128/CMR.17.4.697-728.2004.

Huong PLT, Hien PT, Lan NTP, Tuan DM, Anh DD, Binh TQ. Clinical Patterns and Risk Factors for Pneumonia Caused by Atypical Bacteria in Vietnamese Children. Indian Pediatr 2021;58:1056–8. https://doi.org/10.1007/s13312-021-2373-5.

Goyet S, Vlieghe E, Kumar V, Newell S, Moore CE, Bousfield R, et al. Etiologies and resistance profiles of bacterial community-acquired pneumonia in Cambodian and neighboring countries’ health care settings: a systematic review (1995 to 2012). PLoS One 2014;9:e89637. https://doi.org/10.1371/journal.pone.0089637.

Tran XD, Hoang V-T, Goumballa N, Vu TN, Tran TK, Pham TD, et al. Viral and bacterial microorganisms in Vietnamese children with severe and non-severe pneumonia. Sci Rep 2024;14:120. https://doi.org/10.1038/s41598-023-50657-5.

Pientong C, Ekalaksananan T, Teeratakulpisarn J, Tanuwattanachai S, Kongyingyoes B, Limwattananon C. Atypical bacterial pathogen infection in children with acute bronchiolitis in northeast Thailand. J Microbiol Immunol Infect 2011;44:95–100. https://doi.org/10.1016/j.jmii.2010.02.001.

Loens K, Goossens H, Ieven M. Acute respiratory infection due to Mycoplasma pneumoniae: current status of diagnostic methods. Eur J Clin Microbiol Infect Dis 2010;29:1055–69. https://doi.org/10.1007/s10096-010-0975-2.

Yun KW. Community-acquired pneumonia in children: updated perspectives on its etiology, diagnosis, and treatment. Clin Exp Pediatr 2023;67:80–9. https://doi.org/10.3345/cep.2022.01452.

Wang Z, Ji Y, Zhang J, Su K, Fan H-B, Yang W-W, et al. Investigation on Atypical Pathogens related with Community Acquired Pneumonia and the Factors Associated with Mycoplasma Pneumoniae Infection in Jiangsu, China. Clin Lab 2020;66. https://doi.org/10.7754/Clin.Lab.2019.191036.

Nantanda R, Bwanga F, Najjingo I, Ndeezi G, Tumwine JK. Prevalence, risk factors and outcome of Mycoplasma pneumoniae infection among children in Uganda: a prospective study. Paediatr Int Child Health 2021;41:188–98. https://doi.org/10.1080/20469047.2021.1980698.