Dietary supplements for obesity


Dietary supplements
Weight loss
Nutritional disease


Obesity and associated complications including diabetes, cardiometabolic dysfunction, disability, malignancy and premature mortality are considered epidemic. Research on obesity is therefore of worldwide importance. The development of obesity is a multifactorial phenomenon with contributions from biological, behavioral, genetic and environmental factors. Obesity and its associated issues require various lifestyle modifications and treatment options such medication, exercise, diet, surgery, pharmacological therapy and dietary supplements. Dietary supplements are considered an attractive alternative to traditional therapy due to their low toxicity profile and their accessibility to the general population. Dietary supplements may include one or more dietary ingredients. In this narrative review, we analyze the effects on obesity and obesity-related issues of various natural components. For example, there are a myriad of supplements that have been used as dietary supplements for weight loss such as minerals, vitamins, amino acids, metabolites, herbs, and plant extracts. This narrative review aims to present the benefits and side-effects of several ingredients of dietary supplements for weight loss and treatment of obesity. In particular, the mechanism of action, results of clinical trials, and possible side effects will be presented for the following ingredients: β-Glucans, bitter orange, calcium, vitamin D, chitosan, chromium, cocoa, coleus forskohlii, conjugate linoleic acid, ephedra sinica, fucoxanthin, garcinia cambogia, glucomannan, green coffee, green tea, guar gum, raspberry, hoodia gordonii, irvingia gabonensis, phenylpropylamine, pyruvate, white kidney bean.


[1] Oppert JM. Obesity: Epidemiology, Pathophysiology and Extra-Respiratory Complications. Rev Pneumol Clin 2002;58:63-70.
[2] Vettori A, Paolacci S, Maltese PE, Herbst KL, Cestari M, Michelini S, Michelini S, Samaja M, Bertelli M. Genetic determinants of the effects of training on muscle and adipose tissue homeostasis in obesity associated with lymphedema. Lymphat Res Biol 2021;19:322-33.
[3] Vettori A, Pompucci G, Paolini B, del Ciondolo I, Bressan S, Dundar M, Kenanoğlu S, Unfer V, Bertelli M. Geneob Project genetic background, nutrition and obesity: a review. Eur Rev Med Pharmacol Sci 2019;23:1751-61.
[4] Obesity: Preventing and Managing the Global Epidemic. Report of a WHO Consultation. World Health Organ Tech Rep Ser 2000;894:1-253.
[5] Pagano C, Marin O, Calcagno A, Schiappelli P, Pilon C, Milan G, Bertelli M, Fanin E, Andrighetto G, Federspil G, Vettor R. Increased serum resistin in adults with Prader-Willi Syndrome is related to obesity and not to insulin resistance. J Clin Endocrinol Metab 2005;90:4335-40.
[6] Camilleri G, Kiani AK, Herbst KL, Kaftalli J, Bernini A, Dhuli K, Manara E, Bonetti G, Stuppia L, Paolacci S, Dautaj A, Bertelli M. Genetics of fat deposition. Eur Rev Med Pharmacol Sci 2021;25:14-22.
[7] Ríos-Hoyo A, Gutiérrez-Salmeán G. New dietary supplements for obesity: what we currently know. Curr Obes Rep 2016;5:262-70.
[8] Bhutani S, vanDellen MR, Cooper JA. Longitudinal weight gain and related risk behaviors during the COVID-19 Pandemic in adults in the US. Nutrients 2021;13:671.
[9] Dhuli K, Ceccarini MR, Precone V, Maltese PE, Bonetti G, Paolacci S, Dautaj A, Guerri G, Marceddu G, Beccari T, Michelini S, Bertelli M. Improvement of quality of life by intake of hydroxytyrosol in patients with lymphedema and association of lymphedema genes with obesity. Eur Rev Med Pharmacol Sci 2021;25:33-42.
[10] Batsis JA, Apolzan JW, Bagley PJ, Blunt HB, Divan V, Gill S, Golden A, Gundumraj S, Heymsfield SB, Kahan S, Kopatsis K, Port A, Prout Parks E, Reilly CA, Rubino D, Saunders KH, Shean R, Tabaza L, Stanley A, Tchang BG, Gundumraj S, Kidambi S. A Systematic Review of Dietary Supplements and Alternative Therapies for Weight Loss. Obesity 2021;29:1102-13.
[11] Gregg EW. Secular trends in cardiovascular disease risk factors according to body mass index in US adults. JAMA 2005;293:1868.
[12] Walter S, Kunst A, Mackenbach J, Hofman A, Tiemeier H. Mortality and disability: the effect of overweight and obesity. Int J Obes 2009;33:1410-8.
[13] Office of Dietary Supplements. Mission, Origin, and Mandate. Available at: of%20ODS%20is,health%20for%20the%20U.S.%20 population. Accessed on: 02/07/2022.
[14] Cloetens L, Ulmius M, Johansson-Persson A, Åkesson B, Önning G. Role of dietary Beta-Glucans in the prevention of the Metabolic Syndrome. Nutr Rev 2012;70:444-58.
[15] el Khoury D, Cuda C, Luhovyy BL, Anderson GH. Beta Glucan: health benefits in Obesity and Metabolic Syndrome. J Nutr Metab 2012:1-28.
[16] Kaats GR, Miller H, Preuss HG, Stohs SJ. A 60day double-blind, placebo-controlled safety study involving Citrus Aurantium (Bitter Orange) extract. Food Chem Toxicol 2013;55:358-62.
[17] Zhu W, Cai D, Wang Y, Lin N, Hu Q, Qi Y, Ma S, Amarasekara S. Calcium plus Vitamin D3 supplementation facilitated fat loss in overweight and obese college students with very-low calcium consumption: a randomized controlled trial. Nutr J 2013;12:8.
[18] Patrulea V, Ostafe V, Borchard G, Jordan O. Chitosan as a starting material for wound healing applications. European Eur J Pharm Biopharm 2015;97:417-26.
[19] Brownley KA, Boettiger CA, Young L, Cefalu WT. Dietary chromium supplementation for targeted treatment of diabetes patients with comorbid depression and binge eating. Med Hypotheses 2015;85:45-8.
[20] Vincent JB, Lukaski HC. Chromium. Advances Nutr 2018;9:505-6.
[21] Barišić V, Kopjar M, Jozinović A, Flanjak I, Ačkar Đ, Miličević B, Šubarić D, Jokić S, Babić J. The chemistry behind chocolate production. Molecules 2019;24:3163.
[22] Kavtiha C, Rajamani K, Vadivel E. Select record coleus forskohlii - a comprehensive review on morphology, phytochemistry and pharmacological aspects. J Med Plant Res 2010;4:278-85.
[23] Godard MP, Johnson BA, Richmond SR. Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men. Obes Res 2005;13:1335-43.
[24] Abenhaim L, Moride Y, Brenot F, Rich S, Benichou J, Kurz X, Higenbottam T, Oakley C, Wouters E, Aubier M, Simonneau G, Bégaud B. Appetite-suppressant drugs and the risk of primary pulmonary hypertension. N Engl J Med 1996;335:609-16.
[25] Kamphuis MMJW, Lejeune MPGM, Saris WHM, Westerterp-Plantenga MS. Effect of conjugated linoleic acid supplementation after weight loss on appetite and food intake in overweight subjects. Eur J Clin Nutr 2003;57:1268-74.
[26] Diepvens K, Westerterp KR, Westerterp-Plantenga MS. Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. Am J Physiol Regul Integr Comp Physiol 2007;292:R77-R85.
[27] Peng J, Yuan J-P, Wu C-F, Wang J-H. Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: metabolism and bioactivities relevant to human health. Mar Drugs 2011;9:1806-28.
[28] Hu X, Li Y, Li C, Fu Y, Cai F, Chen Q, Li D. Combination of fucoxanthin and conjugated linoleic acid attenuates body weight gain and improves lipid metabolism in high-fat diet-induced obese rats. Arch Biochem Biophys 2012;519:59-65.
[29] Gammone M, D’Orazio N. Anti-obesity activity of the marine carotenoid fucoxanthin. Mar Drugs 2015;13:2196-214.
[30] Kang S-I, Ko H-C, Shin H-S, Kim H-M, Hong Y-S, Lee N-H, Kim S-J. Fucoxanthin exerts differing effects on 3t3-l1 cells according to differentiation stage and inhibits glucose uptake in mature adipocytes. Biochem Biophys Res Commun 2011;409:769-74.
[31] Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K. Fucoxanthin from edible seaweed, undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. Biochem Biophys Res Commun 2005;332:392-7.
[32] Heymsfield SB, Allison DB, Vasselli JR, Pietrobelli A,Greenfield D, Nunez C. Garcinia Cambogia (hydroxycitric acid) as a potential antiobesity agent. JAMA 1998;280:1596.
[33] Astell KJ, Mathai ML, Su XQ. Plant extracts with appetite suppressing properties for body weight control: a systematic review of double blind randomized controlled clinical trials. Complement Ther Med 2013;21:407-16.
[34] Alonso-Sande M, Teijeiro-Osorio D, Remuñán-López C, Alonso MJ. Glucomannan, a promising polysaccharide for biopharmaceutical purposes. Eur J Pharm Biopharm 2009;72:453-62.
[35] Keithley JK, Swanson B, Mikolaitis SL, DeMeo M, Zeller JM, Fogg L, Adamji J. Safety and efficacy of glucomannan for weight loss in overweight and moderately obese adults. J Obes 2013:1-7.
[36] Sood N, Baker WL, Coleman CI. Effect of Glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: systematic review and meta-analysis. The Am J Clin Nutr 2008;88:1167-75.
[37] Mullin GE. Supplements for weight loss. Nutrition in Clinical Practice 2015;30:311-2.
[38] Flanagan J, Bily A, Rolland Y, Roller M. Lipolytic activity of svetol®, a decaffeinated green coffee bean extract. Phytother Res 2014;28:946-8.
[39] Cho A-S, Jeon S-M, Kim M-J, Yeo J, Seo K-I, Choi M-S, Lee M- K. Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice. Food Chem Toxicol 2010;48:937-43.
[40] Onakpoya I, Terry R, Ernst E. The use of green coffee extract as a weight loss supplement: a systematic review and meta-analysis of randomised clinical trials. Gastroenterol Res Pract 2011:1-6.
[41] Carrasco-Pozo C, Cires MJ, Gotteland M. Quercetin and epigallocatechin gallate in the prevention and treatment of obesity: from molecular to clinical studies. J Med Food 2019;22:753-70.
[42] Pasman W, Westerterp-Plantenga M, Muls E, Vansant G, van Ree J, Saris W. The effectiveness of long-term fibre supplementation on weight maintenance in weight-reduced women. Int J Obes 1997;21:548-55.
[43] Russell PJ, Swindells C. Chemical characterisation of hoodia gordonii extract. Food Chem Toxicol 2012;50:S6-S13.
[44] van Heerden FR. Hoodia gordonii: a natural appetite suppressant. J Ethnopharmacol 2008;119:434-7.
[45] Smith C, Krygsman A. Hoodia Gordonii: to eat, or not to eat. J Ethnopharmacol 2014;155:987-91.
[46] Oben JE, Ngondi JL, Blum K. Inhibition of Irvingia Gabonensis seed extract (OB131) on adipogenesis as mediated via down regulation of the PPARgamma and leptin genes and up-regulation of the adiponectin gene. Lipids Health Dis 2008;7:44.
[47] Yamoneka J, Malumba P, Blecker C, Gindo M, Richard G, Fauconnier M-L, Lognay G, Danthine S. Physicochemical properties and thermal behaviour of african wild mango (Irvingia Gabonensis) seed fat. LWT - Food Science and Technology 2015;64:989-96.
[48] Park K. Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes. Planta Med 2010;76:1654-8.
[49] Greenway F, Heber D, Raum W, Morales S. Double-blind, randomized, placebo-controlled clinical trials with non-prescription medications for the treatment of obesity. Obes Res 1999;7:370-8. tb00420.x
[50] Miller AT, Thomas BM. Pyruvate metabolism in obesity. Am J Clin Nutr 1956;4:619-24.
[51] Obiro WC, Zhang T, Jiang B. The nutraceutical role of the phaseolus vulgaris α-Amylase inhibitor. Br J Nutr 2008;100:1-12.
[52] Sima P, Vannucci L, Vetvicka V. β-Glucans and Cholesterol (Review). Int J Mol Med 2018.
[53] Stohs SJ, Preuss HG, Shara M. The safety of citrus aurantium (Bitter Orange) and its primary protoalkaloid p -Synephrine. Phytother Res 2011;25:1421-8.
[54] Allison DB, Cutter G, Poehlman ET, Moore DR, Barnes S. Exactly which synephrine alkaloids does citrus aurantium (Bitter Orange) contain? Int J Obes 2005;29:443-6.
[55] Bitter Orange. In: Drugs and Lactation Database (LactMed). Bethesda (MD): National Library of Medicine (US) 2021. Available at: Accessed on: 12/08/2022.
[56] van Bennekum AM, Nguyen Dv, Schulthess G, Hauser H, Phillips MC. Mechanisms of cholesterol-lowering effects of dietary insoluble fibres: relationships with intestinal and hepatic cholesterol parameters. Br J Nutr 2005;94:331-7.
[57] Ernst E, Pittler M. Chitosan as a treatment for body weight reduction: a meta-analysis. Available at: https://www. meta%2Danalysis%20implies%20that,raised%20about%20 the%20original%20studies. Accessed on: 12/08/2022.
[58] Woodgate DE, Conquer JA. Effects of a stimulant-free dietary supplement on body weight and fat loss in obese adults: a six-week exploratory study. Curr Ther Res Clin Exp 2003;64:248-62.
[59] Pereira A, Guedes AD, Verreschi ITN, Santos RD, Martinez TLR. A obesidade e sua associação com os demais fatores de risco cardiovascular em escolares de itapetininga, Brasil. Arq Bras Cardiol 2009;93.
[60] Willoughby D, Hewlings S, Kalman D. Body composition changes in weight loss: strategies and supplementation for maintaining lean body mass, a brief review. Nutrients 2018;10:1876.
[61] Greenberg JA, O’Donnell R, Shurpin M, Kordunova D. Epicatechin, procyanidins, cocoa, and appetite: a randomized controlled trial. Am J Clin Nutr 2016;104:613-9.
[62] León-Flores P, Nájera N, Pérez E, Pardo B, Jimenez F, Diaz-Chiguer D, Villarreal F, Hidalgo I, Ceballos G, Meaney E. Effects of cacao by-products and a modest weight loss intervention on the concentration of serum triglycerides in overweight subjects: proof of concept. J Med Food 2020;23:745-9.
[63] Insel PA. Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G Protein Signaling. Cell Mol Neurobiol 2003;23:305-14.
[64] Lee KN, Kritchevsky D, Parizaa MW. Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 1994;108:19-25.
[65] Abidov M, Ramazanov Z, Seifulla R, Grachev S. The effects of xanthigenTM in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat. Diabetes Obes Metab 2010;12:72-81.
[66] Zalewski BM, Szajewska H. No effect of Glucomannan on body weight reduction in children and adolescents with overweight and obesity: a randomized controlled trial. J Pediatr 2019;211:85-91.
[67] Tsao R. Chemistry and biochemistry of dietary polyphenols. Nutrients 2010;2:1231-46.
[68] Chen I-J, Liu C-Y, Chiu J-P, Hsu C-H. Therapeutic effect of high-dose green tea extract on weight reduction: a randomized, double-blind, placebo-controlled clinical trial. Clin Nutr 2016;35:592-9.
[69] MacLean DB, Luo L-G. Increased ATP content/production in the Hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside. Brain Res 2004;1020:1-11. brainres.2004.04.041
[70] Pittler MH, Ernst E. Guar gum for body weight reduction: meta-analysis of randomized trials. Am J Med 2001;110:724-30.
[71] le Nevé B, Foltz M, Daniel H, Gouka R. The steroid Glycoside H. g.-12 from Hoodia Gordonii activates the human bitter receptor TAS2R14 and induces CCK release from HuTu-80 cells. Am J Physiol Gastrointest Liver Physiol 2010;299:G1368-G1375.
[72] Ngondi JL, Oben JE, Minka SR. The Effect of Irvingia Gabonensis seeds on body weight and blood lipids of obese subjects in Cameroon. Lipids Health Dis 2005;4:12.
[73] Oben JE, Ngondi JL, Momo CN, Agbor GA, Sobgui C. The use of a Cissus Quadrangularis/Irvingia Gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
[74] Onakpoya I, Davies L, Posadzki P, Ernst E. The efficacy of Irvingia Gabonensis supplementation in the management of overweight and obesity: a systematic review of randomized controlled trials. J Diet Suppl 2013;10:29-38. 0.3109/19390211.2012.760508
[75] Park KS. Raspberry Ketone, a naturally occurring phenolic compound, inhibits adipogenic and lipogenic gene expression in 3T3-L1 adipocytes. Pharm Biol 2015;53:870-5. https://doi.or g/10.3109/13880209.2014.946059
[76] Morimoto C, Satoh Y, Hara M, Inoue S, Tsujita T, Okuda H. Anti-obese action of Raspberry Ketone. Life Sci 2005;77:194-204.
[77] Bredsdorff L, Wedebye EB, Nikolov NG, Hallas-Møller T, Pilegaard K. Raspberry Ketone in food supplements – high intake, few toxicity data – a cause for safety concern? Regul Toxicol Pharmacol 2015;73:196-200.
[78] Schteingart DE. Effectiveness of phenylpropanolamine in the management of moderate obesity. Int J Obes Relat Metab Disord 1992;16:487-93.
[79] Onakpoya I, Hunt K, Wider B, Ernst E. Pyruvate supplementation for weight loss: a systematic review and meta-analysis of randomized clinical trials. Crit Rev Food Sci Nutr 2014;54:17-23.
[80] Jauhari P, Sankhyan N, Vyas S, Singhi P. Thiamine responsive pyruvate dehydrogenase complex deficiency: a potentially treatable cause of leigh’s disease. J Pediatr Neurosci 2017;12:265-7.
[81] Vinson JA, al Kharrat H, Shuta D. Investigation of an amylase inhibitor on human glucose absorption after starch consumption. Open Nutraceuticals J 2009;2:88-91.
[82] Celleno L, Tolaini MV, D’Amore A, Perricone Nv, Preuss HG. A dietary supplement containing standardized phaseolus vulgaris extract influences body composition of overweight men and women. Int J Med Sci 2007:45-52.