The great rubella epidemic has been sometimes occurred in Japan. We compared the prevalence of rubella antibody in women with pregnancies conceived by infertility treatments and those conceived spontaneously. We reviewed the obstetric records of the Japanese nulliparous women with pregnancies conceived by infertility treatments who had deliveries at Japanese Red Cross Katsushika Maternity Hospital from 2014 to 2018. There were no significant differences in the rate of women whose rubella antibody titer < 8 or < 32, respectively between the 2 groups with pregnancies conceived by infertility treatments and conceived spontaneously (titer < 8: 4.1 vs. 3.4%, p = 0.58: titer < 32: 17.3 vs. 15.3%, p = 0.45). It is necessary to thoroughly implement the preconception care concerning the risk of congenital rubella infection for women who are undergoing infertility treatments especially in Japanese obstetricians.
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